Nuclear Localization Leucine-Rich-Repeat Protein 1 Deficiency Protects Against Cardiac Hypertrophy by Pressure Overload | Zendy

Jing Zong | Zendy; Fangfang Li | Zendy; Kai Liang | Zendy; Rui Dai | Zendy; Hao Zhang | Zendy; Ling Yan | Zendy; Jiali Liu | Zendy; Luhong Xu | Zendy; Wenhao Qian | Zendy

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Nuclear Localization Leucine-Rich-Repeat Protein 1 Deficiency Protects Against Cardiac Hypertrophy by Pressure Overload

Author(s) -

Jing Zong,

Fangfang Li,

Kai Liang,

Rui Dai,

Hao Zhang,

Ling Yan,

Jiali Liu,

Luhong Xu,

Wenhao Qian

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000491664

Subject(s) - muscle hypertrophy , pressure overload , medicine , endocrinology , smad , fibrosis , biology , transforming growth factor , cardiac hypertrophy

Nuclear localization leucine-rich-repeat protein 1 (NLRP1) is a cytoplasmic protein, involved in autoimmune diseases, mammalian reproduction, neuronal cell death, and stroke. However, the role of NLRP1 in cardiac hypertrophy remains unclear. We used in vivo and in vitro models to investigate the effects of NLRP1 on cardiac hypertrophy.

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