Compound K Inhibits Autophagy-Mediated Apoptosis Through Activation of the PI3K-Akt Signaling Pathway Thus Protecting Against Ischemia/Reperfusion Injury | Zendy

Xiangyan Li | Zendy; Qingxia Huang | Zendy; Manying Wang | Zendy; Xiuci Yan | Zendy; Xinying Song | Zendy; Rui Ma | Zendy; Rui Jiang | Zendy; Daqing Zhao | Zendy; Liwei Sun | Zendy

Open Access

Compound K Inhibits Autophagy-Mediated Apoptosis Through Activation of the PI3K-Akt Signaling Pathway Thus Protecting Against Ischemia/Reperfusion Injury

Author(s) -

Xiangyan Li,

Qingxia Huang,

Manying Wang,

Xiuci Yan,

Xinying Song,

Rui Ma,

Rui Jiang,

Daqing Zhao,

Liwei Sun

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000491655

Subject(s) - autophagy , pi3k/akt/mtor pathway , apoptosis , protein kinase b , viability assay , reperfusion injury , microbiology and biotechnology , signal transduction , tunel assay , reactive oxygen species , chemistry , biology , pharmacology , ischemia , biochemistry , medicine

A series of reports revealed that autophagy and apoptosis exerted detrimental effects on the pathology of cardiac ischemia/reperfusion (I/R) injury. Ginsenoside compound K (CK), a major intestinal metabolite underlying the pharmacological actions of orally administered ginseng, has a protective effect against myocardial I/R injury. However, the molecular mechanisms by which CK protects against I/R injury remain unclear. In this study, we hypothesized that the cardioprotective effects of CK against I/R injury are mediated by inhibiting autophagy/apoptosis-related signaling pathways in H9c2 cardiomyocyte cells.

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