A Direct Interaction Between P53-Binding Protein 1 and Minichromosome Maintenance Complex in Hepg2 Cells | Zendy

Yong Chen | Zendy; Chengyin Weng | Zendy; Hui Zhang | Zendy; Jianqun Sun | Zendy; Yawei Yuan | Zendy

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A Direct Interaction Between P53-Binding Protein 1 and Minichromosome Maintenance Complex in Hepg2 Cells

Author(s) -

Yong Chen,

Chengyin Weng,

Hui Zhang,

Jianqun Sun,

Yawei Yuan

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000491607

Subject(s) - chromatin , dna damage , chromatin immunoprecipitation , minichromosome maintenance , immunoprecipitation , microbiology and biotechnology , minichromosome , chemistry , cancer research , gene knockdown , transfection , biology , dna repair , dna , cell culture , apoptosis , promoter , biochemistry , eukaryotic dna replication , genetics , gene expression , gene

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. DNA damage repair in cancer cells is a promising approach for the treatment of cancers. We aimed to explore the potential interaction between p53-binding protein 1 (53BP1) and minichromosome maintenance (MCMs) proteins during DNA damage in human hepatoma HepG2 cells.

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