Sterile Inflammatory Role of High Mobility Group Box 1 Protein: Biological Functions and Involvement in Disease | Zendy

Sera Gonelevue | Zendy; Abhirup Bandyopadhyay | Zendy; Saumya Bhagat | Zendy; Iqbal Alam | Zendy; Gausal A. Khan | Zendy

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Sterile Inflammatory Role of High Mobility Group Box 1 Protein: Biological Functions and Involvement in Disease

Author(s) -

Sera Gonelevue,

Abhirup Bandyopadhyay,

Saumya Bhagat,

Iqbal Alam,

Gausal A. Khan

Publication year - 2018

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000491390

Subject(s) - hmgb1 , inflammation , high mobility group , insulin resistance , medicine , inflammatory response , disease , immunology , diabetes mellitus , bioinformatics , biology , endocrinology , biochemistry , gene

High mobility group box 1 protein (HMGB1), a sterile inflammatory molecule and damage-associated molecular pattern (DAMP) released from various cells during stress has been implicated in inflammation. Several reports show that there is a direct relationship between inflammation and cardiovascular diseases (CVDs) such as thrombosis, hypertension, insulin resistance, preeclampsia, etc. Here, we intend to summarize the concept of the emerging link between HMGB1 and CVDs. Furthermore, we will discuss the possible therapeutic strategies that target HMGB1 for the treatment of different CVDs.

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