A Novel Strategy to Identify Placebo Responders: Prediction Index of Clinical and Biological Markers in the EMBARC Trial | Zendy

Madhukar H. Trivedi | Zendy; Charles South | Zendy; Manish K. Jha | Zendy; A. John Rush | Zendy; Jing Cao | Zendy; Benji T. Kurian | Zendy; Mary L. Phillips | Zendy; Diego A. Pizzagalli | Zendy; Joseph M. Trombello | Zendy; María A. Oquendo | Zendy; Crystal Cooper | Zendy; Daniel G. Dillon | Zendy; Christian A. Webb | Zendy; Bruce D. Grannemann | Zendy; Gerard E. Bruder | Zendy; Patrick J. McGrath | Zendy; Ramin V. Parsey | Zendy; Myrna M. Weissman | Zendy; Maurizio Fava | Zendy

Open Access

A Novel Strategy to Identify Placebo Responders: Prediction Index of Clinical and Biological Markers in the EMBARC Trial

Author(s) -

Madhukar H. Trivedi,

Charles South,

Manish K. Jha,

A. John Rush,

Jing Cao,

Benji T. Kurian,

Mary L. Phillips,

Diego A. Pizzagalli,

Joseph M. Trombello,

María A. Oquendo,

Crystal Cooper,

Daniel G. Dillon,

Christian A. Webb,

Bruce D. Grannemann,

Gerard E. Bruder,

Patrick J. McGrath,

Ramin V. Parsey,

Myrna M. Weissman,

Maurizio Fava

Publication year - 2018

Publication title -

psychotherapy and psychosomatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.531

H-Index - 98

eISSN - 1423-0348

pISSN - 0033-3190

DOI - 10.1159/000491093

Subject(s) - placebo , psychology , clinical trial , neuroticism , medicine , depression (economics) , clinical psychology , personality , social psychology , alternative medicine , economics , macroeconomics , pathology

One in three clinical trial patients with major depressive disorder report symptomatic improvement with placebo. Strategies to mitigate the effect of placebo responses have focused on modifying study design with variable success. Identifying and excluding or controlling for individuals with a high likelihood of responding to placebo may improve clinical trial efficiency and avoid unnecessary medication trials.

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