Molecular Genetics of the Human Neutrophil Antigens | Zendy

Brigitte K. Flesch | Zendy; Angelika Reil | Zendy

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Molecular Genetics of the Human Neutrophil Antigens

Author(s) -

Brigitte K. Flesch,

Angelika Reil

Publication year - 2018

Publication title -

transfusion medicine and hemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 39

eISSN - 1660-3818

pISSN - 1660-3796

DOI - 10.1159/000491031

Subject(s) - immunology , antigen , transfusion related acute lung injury , gene , neutropenia , antibody , biology , medicine , genetics , lung , chemotherapy , pulmonary edema

Antibodies to human neutrophil antigens (HNAs) have been implicated in transfusion-related acute lung injury and allo- and autoimmune neutropenia. To date, five HNA systems are assigned, and during the last decades enormous efforts have been undertaken to identify the underlying genes and to characterize the antigens. This review of the literature will provide the current genetic, molecular and functional information on HNAs.

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