MicroRNA-142-3p Induces Atherosclerosis-Associated Endothelial Cell Apoptosis by Directly Targeting Rictor | Zendy

Bing Qin | Zendy; Yaqing Shu | Zendy; Ling Long | Zendy; Haiyan Li | Zendy; Xuejiao Men | Zendy; Li Feng | Zendy; Huan Yang | Zendy; Zhengqi Lu | Zendy

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MicroRNA-142-3p Induces Atherosclerosis-Associated Endothelial Cell Apoptosis by Directly Targeting Rictor

Author(s) -

Bing Qin,

Yaqing Shu,

Ling Long,

Haiyan Li,

Xuejiao Men,

Li Feng,

Huan Yang,

Zhengqi Lu

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000490932

Subject(s) - apoptosis , microrna , microbiology and biotechnology , cancer research , biology , endothelial stem cell , downregulation and upregulation , chemistry , in vitro , biochemistry , gene

Atherosclerosis, a multifactorial chronic disease, is the main cause of death and impairment in the world. Endothelial cells (ECs) apoptosis plays a crucial role in the onset and development of atherosclerosis, whereas the underlying molecular mechanisms are unclear. MicroRNA-142-3p (miR-142-3p) is a well-defined tumor suppressor in several types of cancer, while the role of miR-142-3p in ECs apoptosis and the development of atherosclerosis has yet to be elucidated. Therefore, the present study aimed to investigate the role of miR-142-3p in ECs apoptosis during atherosclerosis and the underlying mechanism.

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