Knockdown of MiR-20a Enhances Sensitivity of Colorectal Cancer Cells to Cisplatin by Increasing ASK1 Expression | Zendy

Luyao Zhang | Zendy; Liang He | Zendy; Hua Zhang | Zendy; Yan Chen | Zendy

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Knockdown of MiR-20a Enhances Sensitivity of Colorectal Cancer Cells to Cisplatin by Increasing ASK1 Expression

Author(s) -

Luyao Zhang,

Liang He,

Hua Zhang,

Yan Chen

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000490834

Subject(s) - gene knockdown , cisplatin , colorectal cancer , cancer research , apoptosis , microrna , oncology , chemistry , medicine , biology , cancer , gene , chemotherapy , biochemistry

Platinum-based chemotherapy is one of the most important strategies for treatment of colorectal cancer. To improve the therapeutic efficiency, adjuvant drugs were sought to sensitize colorectal cancer cells to platinum-based agents such as cisplatin. As previous research has shown that miRNAs are associated with chemosensitivity, we aimed to alter miRNA regulation in colorectal cancer cells to increase their chemosensitivity.

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