Dexmedetomidine Protects Neural Stem Cells from Ketamine-Induced Injury | Zendy

Pan Lu | Zendy; Shan Lei | Zendy; Weisong Li | Zendy; Yang Lu | Zendy; Juan Zheng | Zendy; Ning Wang | Zendy; Yongjun Xia | Zendy; Haixia Lü | Zendy; Xinlin Chen | Zendy; Yong Liu | Zendy; Pengbo Zhang | Zendy

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Dexmedetomidine Protects Neural Stem Cells from Ketamine-Induced Injury

Author(s) -

Pan Lu,

Shan Lei,

Weisong Li,

Yang Lu,

Juan Zheng,

Ning Wang,

Yongjun Xia,

Haixia Lü,

Xinlin Chen,

Yong Liu,

Pengbo Zhang

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000490823

Subject(s) - dexmedetomidine , neural stem cell , viability assay , protein kinase b , pi3k/akt/mtor pathway , apoptosis , tunel assay , gsk 3 , pharmacology , neuroprotection , neurogenesis , chemistry , ketamine , kinase , microbiology and biotechnology , medicine , stem cell , biology , anesthesia , biochemistry , sedation

Ketamine inhibits the proliferation of neural stem cells (NSCs) and disturbs normal neurogenesis. Dexmedetomidine provides neuroprotection against volatile anesthetic-induced neuroapoptosis and cognitive impairment in the developing brain. Whether it may protect NSCs from ketamine-induced injury remains unknown. In this study, we investigated the protective effects of dexmedetomidine on ketamine-exposed NSCs and explored the mechanisms potentially involved.

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