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Heterogeneity of Epigenetic and Epithelial Mesenchymal Transition Marks in Hepatocellular Carcinoma with Keratin 19 Proficiency
Author(s) -
Naosuke Yokomichi,
Naoshi Nishida,
Yuzo Umeda,
Fumitaka Taniguchi,
Kazuya Yasui,
Toshiaki Toshima,
Yoshiko Mori,
Akihiro Nyuya,
Takehiro Tanaka,
Takeshi Yamada,
Takahito Yagi,
Toshiyoshi Fujiwara,
Yoshiyuki Yamaguchi,
Ajay Goel,
Masatoshi Kudo,
Takeshi Nagasaka
Publication year - 2018
Publication title -
liver cancer
Language(s) - English
Resource type - Journals
eISSN - 2235-1795
pISSN - 1664-5553
DOI - 10.1159/000490806
Subject(s) - hccs , hepatocellular carcinoma , epigenetics , dna methylation , methylation , cancer research , vimentin , carcinoma , pathology , medicine , chemistry , biology , gene expression , immunohistochemistry , dna , genetics , gene
Keratin 19 (K19) expression is a potential predictor of poor prognosis in patients with hepatocellular carcinoma (HCC). To clarify the feature of K19-proficient HCC, we traced epigenetic footprints in cultured cells and clinical materials.

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