TDO2 Overexpression Is Associated with Cancer Stem Cells and Poor Prognosis in Esophageal Squamous Cell Carcinoma | Zendy

Quốc Thắng Phạm | Zendy; Naohide Oue | Zendy; Yohei Sekino | Zendy; Yuji Yamamoto | Zendy; Yoshinori Shigematsu | Zendy; Naoya Sakamoto | Zendy; Kazuhiro Sentani | Zendy; Naohiro Uraoka | Zendy; Wataru Yasui | Zendy

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TDO2 Overexpression Is Associated with Cancer Stem Cells and Poor Prognosis in Esophageal Squamous Cell Carcinoma

Author(s) -

Quốc Thắng Phạm,

Naohide Oue,

Yohei Sekino,

Yuji Yamamoto,

Yoshinori Shigematsu,

Naoya Sakamoto,

Kazuhiro Sentani,

Naohiro Uraoka,

Wataru Yasui

Publication year - 2018

Publication title -

oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.987

H-Index - 98

eISSN - 1423-0232

pISSN - 0030-2414

DOI - 10.1159/000490725

Subject(s) - cancer research , cancer , biology , cd44 , cell culture , cell , medicine , genetics

Esophageal cancer is one of the deadliest cancers in the world, and the main subtype is esophageal squamous cell carcinoma (ESCC), which comprises 90% of cases. Expression of tryptophan 2,3-dioxygenase (TDO2), an enzyme involved in tryptophan catabolism, has been linked with tumor survival and poor prognosis of brain and breast cancer. However, no studies have investigated the potential role of TDO2 in esophageal cancer. Here we explored the expression and biological significance of TDO2 in ESCC.

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