Targeting Regulatory T Cells for Transplant Tolerance: New Insights and Future Perspectives | Zendy

Eman Shaban | Zendy; George Bayliss | Zendy; Deepak Malhotra | Zendy; Douglas Shemin | Zendy; Lijuan Wang | Zendy; Reginald Gohh | Zendy; Lance D. Dworkin | Zendy; Rujun Gong | Zendy

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Targeting Regulatory T Cells for Transplant Tolerance: New Insights and Future Perspectives

Author(s) -

Eman Shaban,

George Bayliss,

Deepak Malhotra,

Douglas Shemin,

Lijuan Wang,

Reginald Gohh,

Lance D. Dworkin,

Rujun Gong

Publication year - 2018

Publication title -

kidney diseases

Language(s) - English

Resource type - Journals

eISSN - 2296-9381

pISSN - 2296-9357

DOI - 10.1159/000490703

Subject(s) - immunosuppression , foxp3 , immune tolerance , immunology , transplantation , immune system , organ transplantation , medicine , regulatory t cell , disease , transplant rejection , biology , bioinformatics , t cell , il 2 receptor

Organ transplantation is considered the ultimate therapy for end-stage organ disease. While pharmacologic immunosuppression is the mainstay of therapeutic strategies to prolong the survival of the graft, long-term use of immunosuppressive medications carries the risk of organ toxicity, malignancies, serious opportunistic infections, and diabetes. Therapies that promote recipient tolerance in solid organ transplantation are able to improve patient outcomes by eliminating the need for long-term immunosuppression.

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