Degradation of Monocyte Chemoattractant Protein-1 by Tryptase Co-Released in Immunoglobulin E-Dependent Activation of Primary Human Cultured Mast Cells | Zendy

Issan Yee San Tam | Zendy; Chun Wai Ng | Zendy; H. Y. A. Lau | Zendy; SeeYing Tam | Zendy

Open Access

Degradation of Monocyte Chemoattractant Protein-1 by Tryptase Co-Released in Immunoglobulin E-Dependent Activation of Primary Human Cultured Mast Cells

Author(s) -

Issan Yee San Tam,

Chun Wai Ng,

H. Y. A. Lau,

SeeYing Tam

Publication year - 2018

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000490533

Subject(s) - tryptase , chemokine , proteases , monocyte , immunoglobulin e , mast cell , immune system , immunology , cytokine , antibody , biology , microbiology and biotechnology , inflammation , chemistry , biochemistry , enzyme

Mast cells are key immune effector cells which release chemokines, proteases, and other inflammatory mediators upon activation by immunological stimuli. The aim of this study was to investigate the effects of co-releasing proteases on the kinetics of release of the chemokine monocyte chemoattractant protein-1 (MCP-1) in immunoglobulin E (IgE)-mediated activation of human mast cells.

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