The Blood Bag Plasticizer Di-2-Ethylhexylphthalate Causes Red Blood Cells to Form Stomatocytes, Possibly by Inducing Lipid Flip-Flop | Zendy

Kathryn A. Melzak | Zendy; Stefanie Uhlig | Zendy; Frank Kirschhöfer | Zendy; Gerald BrennerWeiß | Zendy; Karen Bieback | Zendy

Open Access

The Blood Bag Plasticizer Di-2-Ethylhexylphthalate Causes Red Blood Cells to Form Stomatocytes, Possibly by Inducing Lipid Flip-Flop

Author(s) -

Kathryn A. Melzak,

Stefanie Uhlig,

Frank Kirschhöfer,

Gerald BrennerWeiß,

Karen Bieback

Publication year - 2018

Publication title -

transfusion medicine and hemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 39

eISSN - 1660-3818

pISSN - 1660-3796

DOI - 10.1159/000490502

Subject(s) - phosphatidylserine , red blood cell , flow cytometry , chemistry , annexin , lysis , microvesicle , biochemistry , haemolysis , microbiology and biotechnology , phospholipid , membrane , biology , immunology , microrna , microvesicles , gene

During storage of red blood cell (RBC) concentrates, the plasticizer di-2-ethylhexylphthalate (DEHP) that keeps the blood bags soft leaches out and can be taken up by the RBCs. DEHP is known to be beneficial for the RBC storage quality, but the molecular mechanisms of the action are unknown.

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