Chondroprotective Effects of Hyaluronic Acid-Chitosan Nanoparticles Containing Plasmid DNA Encoding Cytokine Response Modifier A in a Rat Knee Osteoarthritis Model | Zendy

Panghu Zhou | Zendy; Bo Qiu | Zendy; Ronghui Deng | Zendy; Huajie Li | Zendy; Xiongfeng Xu | Zendy; Xifu Shang | Zendy

Open Access

Chondroprotective Effects of Hyaluronic Acid-Chitosan Nanoparticles Containing Plasmid DNA Encoding Cytokine Response Modifier A in a Rat Knee Osteoarthritis Model

Author(s) -

Panghu Zhou,

Bo Qiu,

Ronghui Deng,

Huajie Li,

Xiongfeng Xu,

Xifu Shang

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000490217

Subject(s) - hyaluronic acid , osteoarthritis , cartilage , chemistry , inflammation , microbiology and biotechnology , transfection , medicine , immunology , pathology , biology , biochemistry , anatomy , alternative medicine , gene

Interleukin (IL)-1β plays an essential role in the pathophysiology of osteoarthritis (OA). Cytokine response modifier A (CrmA) can prevent the generation of active IL-1β. This study aimed to explore the chondroprotective effects of hyaluronic acid-chitosan nanoparticles containing plasmid DNA encoding CrmA (HA/CS-CrmA) in a rat OA model.

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