Thymoquinone Attenuates Myocardial Ischemia/Reperfusion Injury Through Activation of SIRT1 Signaling | Zendy

Yunyang Lu | Zendy; Ying-Da Feng | Zendy; Dan Liu | Zendy; Zhiran Zhang | Zendy; Kai Gao | Zendy; Wei Zhang | Zendy; Haifeng Tang | Zendy

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Thymoquinone Attenuates Myocardial Ischemia/Reperfusion Injury Through Activation of SIRT1 Signaling

Author(s) -

Yunyang Lu,

Ying-Da Feng,

Dan Liu,

Zhiran Zhang,

Kai Gao,

Wei Zhang,

Haifeng Tang

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000490216

Subject(s) - cardioprotection , thymoquinone , pharmacology , superoxide dismutase , oxidative stress , reperfusion injury , apoptosis , lactate dehydrogenase , reactive oxygen species , medicine , ischemia , chemistry , biochemistry , antioxidant , enzyme

Myocardial ischemia/reperfusion (MI/R) injury is a leading factor responsible for damage in myocardial infarction, resulting in additional injury to cardiac tissues involved in oxidative stress, inflammation, and apoptosis. Thymoquinone (TQ), the main constituent of Nigella sativa L. seeds, has been reported to possess various biological activities. However, few reports regarding myocardial protection are available at present. Therefore, this study was conducted aiming to investigate the protective effect of TQ against MI/R injury and to clarify its potential mechanism.

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