Rapid Electrical Stimulation Increased Cardiac Apoptosis Through Disturbance of Calcium Homeostasis and Mitochondrial Dysfunction in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes | Zendy

Le Geng | Zendy; Zidun Wang | Zendy; Chang Cui | Zendy; Yue Zhu | Zendy; Jiaojiao Shi | Zendy; Jiaxian Wang | Zendy; Minglong Chen | Zendy

Open Access

Rapid Electrical Stimulation Increased Cardiac Apoptosis Through Disturbance of Calcium Homeostasis and Mitochondrial Dysfunction in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Author(s) -

Le Geng,

Zidun Wang,

Chang Cui,

Yue Zhu,

Jiaojiao Shi,

Jiaxian Wang,

Minglong Chen

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000490213

Subject(s) - calcium , apoptosis , biology , propidium iodide , stimulation , annexin , medicine , endocrinology , microbiology and biotechnology , calmodulin , downregulation and upregulation , induced pluripotent stem cell , programmed cell death , biochemistry , gene , embryonic stem cell

Heart failure induced by tachycardia, the most common arrhythmia, is frequently observed in clinical practice. This study was designed to investigate the underlying mechanisms.

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