Depletion of Cholesterol Reduces ENaC Activity by Decreasing Phosphatidylinositol-4,5-Bisphosphate in Microvilli | Zendy

Yujia Zhai | Zendy; Bingchen Liu | Zendy; Shipeng Wei | Zendy; ChuFang Chou | Zendy; MingMing Wu | Zendy; BinLin Song | Zendy; Valerie Linck | Zendy; Li Zou | Zendy; Shuai Zhang | Zendy; Xueqi Li | Zendy; ZhiRen Zhang | Zendy; HePing Ma | Zendy

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Depletion of Cholesterol Reduces ENaC Activity by Decreasing Phosphatidylinositol-4,5-Bisphosphate in Microvilli

Author(s) -

Yujia Zhai,

Bingchen Liu,

Shipeng Wei,

ChuFang Chou,

MingMing Wu,

BinLin Song,

Valerie Linck,

Li Zou,

Shuai Zhang,

Xueqi Li,

ZhiRen Zhang,

HePing Ma

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000490170

Subject(s) - epithelial sodium channel , apical membrane , chinese hamster ovary cell , microbiology and biotechnology , chemistry , amiloride , epithelial polarity , phosphatidylinositol , biology , cell , biochemistry , membrane , sodium , signal transduction , receptor , organic chemistry

The epithelial sodium channel (ENaC) in cortical collecting duct (CCD) principal cells plays a critical role in regulating systemic blood pressure. We have previously shown that cholesterol (Cho) in the apical cell membrane regulates ENaC; however, the underlying mechanism remains unclear.

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