Exosomes from MiR-30d-5p-ADSCs Reverse Acute Ischemic Stroke-Induced, Autophagy-Mediated Brain Injury by Promoting M2 Microglial/Macrophage Polarization | Zendy

Mei Jiang | Zendy; Hairong Wang | Zendy; Mingming Jin | Zendy; Xuelian Yang | Zendy; HaiFeng Ji | Zendy; Yufeng Jiang | Zendy; Hanwen Zhang | Zendy; Feifei Wu | Zendy; Guolu Wu | Zendy; Xiaoyin Lai | Zendy; Liying Cai | Zendy; Rongguo Hu | Zendy; Limin Xu | Zendy; Longxuan Li | Zendy

Open Access

Exosomes from MiR-30d-5p-ADSCs Reverse Acute Ischemic Stroke-Induced, Autophagy-Mediated Brain Injury by Promoting M2 Microglial/Macrophage Polarization

Author(s) -

Mei Jiang,

Hairong Wang,

Mingming Jin,

Xuelian Yang,

HaiFeng Ji,

Yufeng Jiang,

Hanwen Zhang,

Feifei Wu,

Guolu Wu,

Xiaoyin Lai,

Liying Cai,

Rongguo Hu,

Limin Xu,

Longxuan Li

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000490078

Subject(s) - autophagy , microvesicles , microglia , exosome , macrophage polarization , medicine , inflammation , proinflammatory cytokine , m2 macrophage , microbiology and biotechnology , macrophage , microrna , cancer research , immunology , in vitro , chemistry , biology , apoptosis , biochemistry , gene

Recent studies have indicated that exosomes secreted from adipose-derived stem cells (ADSCs) have important effects in the treatment of ischemic injury. However, the treatment mechanism is unclear. This study aimed to investigate whether ADSC-derived exosomes enriched with microRNA (miR)-30d-5p have a protective effect on acute ischemic stroke (AIS).

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