Paeoniflorin Attenuates Inflammatory Pain by Inhibiting Microglial Activation and Akt-NF-κB Signaling in the Central Nervous System | Zendy

Bo Hu | Zendy; Guangtao Xu | Zendy; Xiaomin Zhang | Zendy; Long Xu | Zendy; Hong Zhou | Zendy; Zhenyi Ma | Zendy; Xiaohua Shen | Zendy; Jia Zhu | Zendy; Ruilin Shen | Zendy

Open Access

Paeoniflorin Attenuates Inflammatory Pain by Inhibiting Microglial Activation and Akt-NF-κB Signaling in the Central Nervous System

Author(s) -

Bo Hu,

Guangtao Xu,

Xiaomin Zhang,

Long Xu,

Hong Zhou,

Zhenyi Ma,

Xiaohua Shen,

Jia Zhu,

Ruilin Shen

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000490076

Subject(s) - proinflammatory cytokine , microglia , pharmacology , protein kinase b , in vivo , medicine , central nervous system , western blot , inflammation , nf κb , signal transduction , nociception , immunology , chemistry , biology , receptor , biochemistry , microbiology and biotechnology , gene

Paeoniflorin (PF) is known to have anti-inflammatory and paregoric effects, but the mechanism underlying its analgesic effect remains unclear. The aim of this study was to clarify the effect of PF on Freund's complete adjuvant (CFA)-induced inflammatory pain and explore the underlying molecular mechanism.

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