Icariin Protects against Glucocorticoid-Induced Osteonecrosis of the Femoral Head in Rats | Zendy

Zengfa Huang | Zendy; Cheng Cheng | Zendy; Beibei Cao | Zendy; Jing Wang | Zendy; Hui Wei | Zendy; Xianzhe Liu | Zendy; Yu Han | Zendy; Shuhua Yang | Zendy; Xiang Wang | Zendy

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Icariin Protects against Glucocorticoid-Induced Osteonecrosis of the Femoral Head in Rats

Author(s) -

Zengfa Huang,

Cheng Cheng,

Beibei Cao,

Jing Wang,

Hui Wei,

Xianzhe Liu,

Yu Han,

Shuhua Yang,

Xiang Wang

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000490023

Subject(s) - icariin , femoral head , glucocorticoid , medicine , endocrinology , pharmacology , chemistry , pathology , anatomy , alternative medicine

Glucocorticoid (GC)-related osteonecrosis of the femoral head (ONFH) is a common complication following administration of steroids to treat many diseases. Our previous study demonstrated that icariin (ICA) might have a beneficial effect on the bone marrow mesenchymal stem cells (BMSCs) of patients with steroid-associated osteonecrosis. In this study, we investigated the underlying mechanisms of ICA associated with the potential enhancement of osteogenesis and anti-adipogenesis in GC-related ONFH.

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