By Activating Akt/eNOS Bilobalide B Inhibits Autophagy and Promotes Angiogenesis Following Focal Cerebral Ischemia Reperfusion | Zendy

Yongqiu Zheng | Zendy; Zhenzhen Wu | Zendy; Frank Yi | Zendy; Matthew Orange | Zendy; Mingjiang Yao | Zendy; Bin Yang | Zendy; Jianxun Liu | Zendy; Hua Zhu | Zendy

Open Access

By Activating Akt/eNOS Bilobalide B Inhibits Autophagy and Promotes Angiogenesis Following Focal Cerebral Ischemia Reperfusion

Author(s) -

Yongqiu Zheng,

Zhenzhen Wu,

Frank Yi,

Matthew Orange,

Mingjiang Yao,

Bin Yang,

Jianxun Liu,

Hua Zhu

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000490016

Subject(s) - protein kinase b , enos , pharmacology , ginkgo biloba , medicine , ischemia , angiogenesis , neuroprotection , reperfusion injury , stroke (engine) , apoptosis , chemistry , nitric oxide synthase , nitric oxide , biochemistry , mechanical engineering , engineering

Ischemic stroke is a leading cause of long-term disability. To date, there is no effective treatment for stroke. Previous studies have shown that Ginkgo biloba extract has protective effects against neurodegenerative disorders. In this present study, we sought to test the potential protective role of an active component of Ginkgo biloba extract, bilobalide, in a rat model of middle cerebral artery occlusion (MCAO).

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