Gremlin2 Regulates the Differentiation and Function of Cardiac Progenitor Cells via the Notch Signaling Pathway | Zendy

Wei Li | Zendy; LU Yao-jun | Zendy; Ruijuan Han | Zendy; Qiang Yue | Zendy; Xiurong Song | Zendy; Fei Wang | Zendy; Rina Wu | Zendy; Feng Hou | Zendy; Yang Liu | Zendy; Lijuan Xu | Zendy; Ruiping Zhao | Zendy; Jiang Hu | Zendy

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Gremlin2 Regulates the Differentiation and Function of Cardiac Progenitor Cells via the Notch Signaling Pathway

Author(s) -

Wei Li,

LU Yao-jun,

Ruijuan Han,

Qiang Yue,

Xiurong Song,

Fei Wang,

Rina Wu,

Feng Hou,

Yang Liu,

Lijuan Xu,

Ruiping Zhao,

Jiang Hu

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000490012

Subject(s) - notch signaling pathway , microbiology and biotechnology , progenitor cell , function (biology) , signal transduction , cardiac function curve , hes3 signaling axis , progenitor , cellular differentiation , chemistry , biology , stem cell , medicine , heart failure , biochemistry , gene

The transplantation of cardiac progenitor cells (CPCs) improves neovascularization and left ventricular function after myocardial infarction (MI). The bone morphogenetic protein antagonist Gremlin 2 (Grem2) is required for early cardiac development and cardiomyocyte differentiation. The present study examined the role of Grem2 in CPC differentiation and cardiac repair.

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