Intravenous Anesthetics Enhance the Ability of Human Bone Marrow-Derived Mesenchymal Stem Cells to Alleviate Hepatic Ischemia-Reperfusion Injury in a Receptor-Dependent Manner | Zendy

Jiayu Feng | Zendy; Weifeng Yao | Zendy; Yihan Zhang | Zendy; Andy Peng Xiang | Zendy; Dongdong Yuan | Zendy; Ziqing Hei | Zendy

Open Access

Intravenous Anesthetics Enhance the Ability of Human Bone Marrow-Derived Mesenchymal Stem Cells to Alleviate Hepatic Ischemia-Reperfusion Injury in a Receptor-Dependent Manner

Author(s) -

Jiayu Feng,

Weifeng Yao,

Yihan Zhang,

Andy Peng Xiang,

Dongdong Yuan,

Ziqing Hei

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000489989

Subject(s) - mesenchymal stem cell , medicine , pharmacology , midazolam , reperfusion injury , propofol , dexmedetomidine , anesthesia , ischemia , pathology , sedation

The degree of hepatic ischemia-reperfusion injury (HIRI) is highly relevant to the incidence of postoperative liver failure and mortality. Bone marrow-derived mesenchymal stem cells (BM-MSCs) have been shown to migrate to the liver and restore the damaged liver. Intravenous anesthetics are commonly used in the perioperative period; however, it is not yet known whether they have an influence on the functions of BM-MSCs and eventually affect the recovery of HIRI.

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