Endogenous Hydrogen Sulfide Ameliorates NOX4 Induced Oxidative Stress in LPS-Stimulated Macrophages and Mice | Zendy

Xiling Wang | Zendy; LiLong Pan | Zendy; Fen Long | Zendy; Weijun Wu | Zendy; Di Yan | Zendy; Peng Xu | Zendy; Siyu Liu | Zendy; Ming Qin | Zendy; Wanwan Jia | Zendy; Xinhua Liu | Zendy; Yi Zhun Zhu | Zendy

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Endogenous Hydrogen Sulfide Ameliorates NOX4 Induced Oxidative Stress in LPS-Stimulated Macrophages and Mice

Author(s) -

Xiling Wang,

LiLong Pan,

Fen Long,

Weijun Wu,

Di Yan,

Peng Xu,

Siyu Liu,

Ming Qin,

Wanwan Jia,

Xinhua Liu,

Yi Zhun Zhu

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000489980

Subject(s) - nox4 , nadph oxidase , oxidative stress , inflammation , protein kinase b , lipopolysaccharide , knockout mouse , gene knockdown , pi3k/akt/mtor pathway , chemistry , signal transduction , reactive oxygen species , biology , microbiology and biotechnology , immunology , biochemistry , apoptosis , receptor

Sepsis is a severe and complicated syndrome that is characterized by dysregulation of host inflammatory responses and organ failure. Cystathionine-γ-lyase (CSE)/ hydrogen sulfide (H2S) has potential anti-inflammatory activities in a variety of inflammatory diseases. NADPH oxidase 4 (Nox4), a member of the NADPH oxidases, is the major source of reactive oxygen species (ROS) and its expression is increased in sepsis, but its function in CSE-mediated anti-inflammatory activities remains unknown.

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