Ethylenediaminetetraacetic Acid Inhibits Vibrio Vulnificus-Induced Dendritic Cell Apoptosis by Lowering [Ca2+]i | Zendy

Ping Qian | Zendy; Bo Hu | Zendy; Yuzhang Zhu | Zendy; Dongliang Shao | Zendy; Huaifeng Zhang | Zendy; Huafei Huang | Zendy; Lizhong Wang | Zendy; Ruilin Shen | Zendy

Open Access

Ethylenediaminetetraacetic Acid Inhibits Vibrio Vulnificus-Induced Dendritic Cell Apoptosis by Lowering [Ca2+]i

Author(s) -

Ping Qian,

Bo Hu,

Yuzhang Zhu,

Dongliang Shao,

Huaifeng Zhang,

Huafei Huang,

Lizhong Wang,

Ruilin Shen

Publication year - 2018

Publication title -

neurosignals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.755

H-Index - 67

eISSN - 1424-8638

pISSN - 1424-862X

DOI - 10.1159/000489951

Subject(s) - vibrio vulnificus , apoptosis , ethylenediaminetetraacetic acid , pi3k/akt/mtor pathway , biology , flow cytometry , microbiology and biotechnology , signal transduction , chemistry , bacteria , biochemistry , chelation , genetics , organic chemistry

Vibrio vulnificus (V. vulnificus) is a Gram-negative marine bacterium that can cause life-threatening primary septicemia, especially in the innate immune system. But how V. vulnificus affects and acts on dendritic cells (DC) is not well understood. The aim of the present study is to investigate [Ca2+]i change and the expression of the mTor-STAT3-Bcl-2 signaling pathway in V. vulnificus B2-induced DC apoptosis, and explore the protective effect of ethylenediaminetetraacetic acid (EDTA) against DC apoptosis in a V. vulnificus B2 and DC2.4 cell coculture infection model, using EDTA as an intervenient.

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