In Vitro Study of Endotoxin Adsorption by a Polymyxin B-Immobilized Fiber Column | Zendy

Chizuru Yamashita | Zendy; Kazuhiro Moriyama | Zendy; Daisuke Hasegawa | Zendy; Yu Kato | Zendy; Toshikazu Sakai | Zendy; Takahiro Kawaji | Zendy; Yasuyo Shimomura | Zendy; Yasuyoshi Kurimoto | Zendy; Mariko Nagata | Zendy; Osamu Nishida | Zendy

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In Vitro Study of Endotoxin Adsorption by a Polymyxin B-Immobilized Fiber Column

Author(s) -

Chizuru Yamashita,

Kazuhiro Moriyama,

Daisuke Hasegawa,

Yu Kato,

Toshikazu Sakai,

Takahiro Kawaji,

Yasuyo Shimomura,

Yasuyoshi Kurimoto,

Mariko Nagata,

Osamu Nishida

Publication year - 2018

Publication title -

blood purification

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.686

H-Index - 57

eISSN - 1421-9735

pISSN - 0253-5068

DOI - 10.1159/000489920

Subject(s) - adsorption , polymyxin , chromatography , polymyxin b , septic shock , chemistry , in vitro , fetal bovine serum , medicine , immunology , biochemistry , sepsis , antibiotics , organic chemistry

Polymyxin B-immobilized fiber (PMX-F) columns are used as therapeutic interventions for septic shock. The clinical efficacy has been reported for 2-h applications, but their ability to adsorb endotoxin over longer treatments has not been fully elucidated. We hypothesized that PMX-F columns are capable of endotoxin removal for more than 2 h.

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