Open AccessType 2 Diabetes Promotes Cell Centrosome Amplification via AKT-ROS-Dependent Signalling of ROCK1 and 14-3-3σ
Author(s) -
Pu Wang,
Yucheng Lu,
Jie Wang,
Lan Wang,
Hanry Yu,
Yuan Fei Li,
Alice P.S. Kong,
Juliana C.N. Chan,
Shaochin Lee
Publication year - 2018
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000489812
Subject(s) - centrosome , biology , microbiology and biotechnology , protein kinase b , palmitic acid , phosphorylation , apoptosis , biochemistry , fatty acid , cell cycle
Type 2 diabetes is associated with oxidative stress and DNA damage which can cause centrosome amplification. Thus, the study investigated centrosome amplification in type 2 diabetes and the underlying mechanisms.
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