MiR-598 Suppresses Invasion and Migration by Negative Regulation of Derlin-1 and Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer
Author(s) -
Fengming Yang,
Ke Wei,
Zhiqiang Qin,
Weitao Liu,
Chuchu Shao,
Chaoshan Wang,
Ling Ma,
Mengyan Xie,
Yongqian Shu,
Hua Shen
Publication year - 2018
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000489803
Subject(s) - vimentin , epithelial–mesenchymal transition , western blot , microrna , cancer research , cell migration , immunohistochemistry , cell growth , lung cancer , biology , cell , gentamicin protection assay , cell culture , luciferase , cancer , pathology , transfection , metastasis , medicine , immunology , gene , biochemistry , genetics
MicroRNAs regulate a wide range of biological processes of non-small cell lung cancer (NSCLC). Although miR-598 has been reported to act as a suppressor in osteosarcoma and colorectal cancer, the physiological function of miR-598 in NSCLC remains unknown. In this study, the role of miR-598 in NSCLC was investigated.
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