A functional Variant (Rs35592567) in TP63 at 3q28 is Associated with Gastric Cancer Risk via Modifying its Regulation by MicroRNA-140 | Zendy

Chao-min Lu | Zendy; Yongwei Yang | Zendy; Siyue Ma | Zendy

Open Access

A functional Variant (Rs35592567) in TP63 at 3q28 is Associated with Gastric Cancer Risk via Modifying its Regulation by MicroRNA-140

Author(s) -

Chao-min Lu,

Yongwei Yang,

Siyue Ma

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000489802

Subject(s) - transfection , microrna , flow cytometry , viability assay , luciferase , cell cycle , mtt assay , microbiology and biotechnology , carcinogenesis , biology , apoptosis , cell growth , western blot , cancer research , cell culture , cancer , gene , genetics

TP63 was believed to play an important role in the development of many malignancies, while the polymorphisms located at the miRNA binding sites within the 3'UTR of TP63 mRNA may interfere with its expression. In this study, we aimed to study the role of TP63 regulation in the tumorigenesis of gastric cancer (GC).

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