Connexin 43 Modulates Osteogenic Differentiation of Bone Marrow Stromal Cells Through GSK-3beta/Beta-Catenin Signaling Pathways | Zendy

Fei-Xiang Lin | Zendy; Guizhou Zheng | Zendy; Bo-Jui Chang | Zendy; Rongchun Chen | Zendy; Qihao Zhang | Zendy; Peng Xie | Zendy; Da Xie | Zendy; Guoyong Yu | Zendy; Qin-Xiao Hu | Zendy; Dezhong Liu | Zendy; Shixin Du | Zendy; Xuedong Li | Zendy

Open Access

Connexin 43 Modulates Osteogenic Differentiation of Bone Marrow Stromal Cells Through GSK-3beta/Beta-Catenin Signaling Pathways

Author(s) -

Fei-Xiang Lin,

Guizhou Zheng,

Bo-Jui Chang,

Rongchun Chen,

Qihao Zhang,

Peng Xie,

Da Xie,

Guoyong Yu,

Qin-Xiao Hu,

Dezhong Liu,

Shixin Du,

Xuedong Li

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000489763

Subject(s) - bone sialoprotein , chemistry , runx2 , stromal cell , gene knockdown , microbiology and biotechnology , alkaline phosphatase , osteocalcin , cellular differentiation , small hairpin rna , signal transduction , cancer research , biology , biochemistry , apoptosis , gene , enzyme

Bone marrow stromal cells (BMSCs) are multipotent precursors that give rise to osteoblasts, and contribute directly to bone formation. Connexin 43 (Cx43) is the most ubiquitous gap junction protein expressed in bone cell types, and plays crucial roles in regulating intercellular signal transmission for bone development, differentiation and pathology. However, the precise role and mechanism of Cx43 in BMSCs are less known. Here, we investigate the function of Cx43 in osteogenic differentiation of BMSCs in vitro.

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