Cardiac Ablation of SOCS3 Aggravates DOCA-Salt-Induced Hypertrophic Remodeling by Activation of Gp130-Dependent Signaling in Mice | Zendy

Shuang Liu | Zendy; Lixin Liu | Zendy; YunLong Zhang | Zendy; Song Lai | Zendy; Yunpeng Xie | Zendy; Nannan Li | Zendy; Hongxia Wang | Zendy; Yunlong Xia | Zendy; Ying Liu | Zendy; HuiHua Li | Zendy

Open Access

Cardiac Ablation of SOCS3 Aggravates DOCA-Salt-Induced Hypertrophic Remodeling by Activation of Gp130-Dependent Signaling in Mice

Author(s) -

Shuang Liu,

Lixin Liu,

YunLong Zhang,

Song Lai,

Yunpeng Xie,

Nannan Li,

Hongxia Wang,

Yunlong Xia,

Ying Liu,

HuiHua Li

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000489757

Subject(s) - socs3 , endocrinology , cardiac fibrosis , medicine , fibrosis , glycoprotein 130 , ventricular remodeling , inflammation , heart failure , eplerenone , mineralocorticoid receptor , receptor , interleukin 6 , cancer , suppressor

Cardiac remodeling is a critical pathogenetic process leading to heart failure. Suppressor of cytokine signaling-3 (SOCS3) is demonstrated as a key negative regulator of the gp130 receptor to inhibit cardiac hypertrophy. However, the role of SOCS3 in deoxycorticosterone-acetate (DOCA)-salt-induced cardiac remodeling remains unclear.

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