5-Aminolevulinic Acid-Mediated Sonodynamic Therapy Alleviates Atherosclerosis via Enhancing Efferocytosis and Facilitating a Shift in the Th1/Th2 Balance Toward Th2 Polarization | Zendy

Yang Yang | Zendy; Yuanyuan Liu | Zendy; Xi Chen | Zendy; Jie Gong | Zendy; Zhen Huang | Zendy; Wei Wang | Zendy; Yuanqi Shi | Zendy; Yu Wang | Zendy; Jianting Yao | Zendy; Zhaoqian Shen | Zendy; Zhen Tian | Zendy; Hong Jin | Zendy; Ye Tian | Zendy

Open Access

5-Aminolevulinic Acid-Mediated Sonodynamic Therapy Alleviates Atherosclerosis via Enhancing Efferocytosis and Facilitating a Shift in the Th1/Th2 Balance Toward Th2 Polarization

Author(s) -

Yang Yang,

Yuanyuan Liu,

Xi Chen,

Jie Gong,

Zhen Huang,

Wei Wang,

Yuanqi Shi,

Yu Wang,

Jianting Yao,

Zhaoqian Shen,

Zhen Tian,

Hong Jin,

Ye Tian

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000489751

Subject(s) - sonodynamic therapy , apoptosis , jurkat cells , efferocytosis , microbiology and biotechnology , biology , chemistry , immunology , macrophage , t cell , biochemistry , in vitro , immune system

We and other groups have demonstrated that 5-aminolevulinic acid (ALA)-mediated sonodynamic therapy (ALA-SDT) induces macrophage and foam cell apoptosis and stabilizes atherosclerosis (AS) plaques in animal models. Lymphocytes also play vital roles in the development of AS. The primary purpose of the present study was to investigate the effects of ALA-SDT on T helper (Th) cell fate and function, Th subset differentiation, and atherosclerotic lesion stability.

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