Serum from Chronic Hepatitis B Patients Promotes Growth and Proliferation via the IGF-II/IGF-IR/MEK/ERK Signaling Pathway in Hepatocellular Carcinoma Cells | Zendy

Yuanyuan Ji | Zendy; Zhidong Wang | Zendy; Haiyan Chen | Zendy; Lei Zhang | Zendy; Fei Zhuo | Zendy; Qingqing Yang | Zendy

Open Access

Serum from Chronic Hepatitis B Patients Promotes Growth and Proliferation via the IGF-II/IGF-IR/MEK/ERK Signaling Pathway in Hepatocellular Carcinoma Cells

Author(s) -

Yuanyuan Ji,

Zhidong Wang,

Haiyan Chen,

Lei Zhang,

Fei Zhuo,

Qingqing Yang

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000489744

Subject(s) - hepatocellular carcinoma , cell growth , mapk/erk pathway , cancer research , transfection , growth factor , insulin like growth factor , small interfering rna , cell culture , biology , signal transduction , chemistry , microbiology and biotechnology , medicine , receptor , genetics

Chronic hepatitis B virus (HBV) infection (CHB) plays a central role in the etiology of hepatocellular carcinoma (HCC). Emerging evidence implicates insulin-like growth factor (IGF)-II as a major risk factor for the growth and development of HCC. However, the relationship between HBV infection and IGF-II functions remains to be elucidated.

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