Downregulation of S100A4 Alleviates Cardiac Fibrosis via Wnt/β -Catenin Pathway in Mice | Zendy

Lijun Qian | Zendy; Jian Hong | Zendy; Yanmei Zhang | Zendy; Menglin Zhu | Zendy; XinChun Wang | Zendy; YanJuan Zhang | Zendy; Ming Chu | Zendy; Jing Yao | Zendy; Di Xu | Zendy

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Downregulation of S100A4 Alleviates Cardiac Fibrosis via Wnt/β -Catenin Pathway in Mice

Author(s) -

Lijun Qian,

Jian Hong,

Yanmei Zhang,

Menglin Zhu,

XinChun Wang,

YanJuan Zhang,

Ming Chu,

Jing Yao,

Di Xu

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000489683

Subject(s) - fibrosis , cardiac fibrosis , downregulation and upregulation , medicine , myocardial fibrosis , wnt signaling pathway , cardiac function curve , gene knockdown , masson's trichrome stain , myocardial infarction , ligation , blot , pathology , signal transduction , cancer research , apoptosis , biology , microbiology and biotechnology , heart failure , biochemistry , gene

Cardiac fibrosis is a pathological change leading to cardiac remodeling during the progression of myocardial ischemic diseases, and its therapeutic strategy remains to be explored. S100A4, a calcium-binding protein, participates in fibrotic diseases with an unclear mechanism. This study aimed to investigate the role of S100A4 in cardiac fibrosis.

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