Association of MiRNA-146a, MiRNA-499, IRAK1 and PADI4 Polymorphisms with Rheumatoid Arthritis in Egyptian Population | Zendy

Olfat Shaker | Zendy; Noha A. El-Boghdady | Zendy; Abeer El-Dessouki El Sayed | Zendy

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Association of MiRNA-146a, MiRNA-499, IRAK1 and PADI4 Polymorphisms with Rheumatoid Arthritis in Egyptian Population

Author(s) -

Olfat Shaker,

Noha A. El-Boghdady,

Abeer El-Dessouki El Sayed

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000489592

Subject(s) - genotype , medicine , single nucleotide polymorphism , rheumatoid arthritis , allele , disease , taqman , immunology , population , genetics , polymerase chain reaction , biology , gene , environmental health

Rheumatoid arthritis (RA) is a systemic autoimmune disease affecting up to 1% of the population worldwide. The aim of the present study was to investigate whether miRNA-146a rs2910164, miRNA-499 rs3746444, IRAK1 rs3027898 and PADI4 rs1748033 polymorphisms are associated with susceptibility to RA in Egyptians and whether they influence disease severity and activity.

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