Downregulated PITX1 Modulated by MiR-19a-3p Promotes Cell Malignancy and Predicts a Poor Prognosis of Gastric Cancer by Affecting Transcriptionally Activated PDCD5 | Zendy

Fengchang Qiao | Zendy; Pihai Gong | Zendy; Yunwei Song | Zendy; Xiaohui Shen | Zendy; Xianwei Su | Zendy; Yiping Li | Zendy; Huazhang Wu | Zendy; Zhujiang Zhao | Zendy; Hong Fan | Zendy

Open Access

Downregulated PITX1 Modulated by MiR-19a-3p Promotes Cell Malignancy and Predicts a Poor Prognosis of Gastric Cancer by Affecting Transcriptionally Activated PDCD5

Author(s) -

Fengchang Qiao,

Pihai Gong,

Yunwei Song,

Xiaohui Shen,

Xianwei Su,

Yiping Li,

Huazhang Wu,

Zhujiang Zhao,

Hong Fan

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000489590

Subject(s) - carcinogenesis , gene knockdown , cell growth , biology , microbiology and biotechnology , transcription factor , reporter gene , electrophoretic mobility shift assay , apoptosis , gene expression , cancer research , gene , genetics

PITX1 has been identified as a potential tumor-suppressor gene in several malignant tumors. The molecular mechanism underlying PITX1, particularly its function as a transcription factor regulating gene expression during tumorigenesis, is still poorly understood.

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