Long Non-Coding RNA SH3PXD2A-AS1 Promotes Cell Progression Partly Through Epigenetic Silencing P57 and KLF2 in Colorectal Cancer | Zendy

Zhonghua Ma | Zendy; Peng Peng | Zendy; Jing Zhou | Zendy; Bingqing Hui | Zendy; Hao Ji | Zendy; Juan Wang | Zendy; Keming Wang | Zendy

Open Access

Long Non-Coding RNA SH3PXD2A-AS1 Promotes Cell Progression Partly Through Epigenetic Silencing P57 and KLF2 in Colorectal Cancer

Author(s) -

Zhonghua Ma,

Peng Peng,

Jing Zhou,

Bingqing Hui,

Hao Ji,

Juan Wang,

Keming Wang

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000489589

Subject(s) - cancer research , chromatin immunoprecipitation , biology , carcinogenesis , gene knockdown , long non coding rna , cell growth , klf2 , colorectal cancer , gene silencing , cell culture , microbiology and biotechnology , cancer , gene expression , downregulation and upregulation , gene , promoter , genetics

Colorectal cancer (CRC) is one of the most commonly diagnosed malignancies worldwide. Current evidence has revealed the key roles of long non-coding RNAs (IncRNAs) in multiple cancers, including CRC. In this study we identified the lncRNA SH3PXD2A-AS1 as a novel molecule associated with CRC progression by analyzing the publicly available data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets.

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