PIK3R3 Promotes Metastasis of Pancreatic Cancer via ZEB1 Induced Epithelial-Mesenchymal Transition | Zendy

Yunpeng Peng | Zendy; Yi Zhu | Zendy; Lingdi Yin | Zendy; Jishu Wei | Zendy; Xinchun Liu | Zendy; Xiaole Zhu | Zendy; Yi Miao | Zendy

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PIK3R3 Promotes Metastasis of Pancreatic Cancer via ZEB1 Induced Epithelial-Mesenchymal Transition

Author(s) -

Yunpeng Peng,

Yi Zhu,

Lingdi Yin,

Jishu Wei,

Xinchun Liu,

Xiaole Zhu,

Yi Miao

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000489382

Subject(s) - gene knockdown , metastasis , pancreatic cancer , biology , cancer research , epithelial–mesenchymal transition , immunohistochemistry , cancer cell , in vivo , cancer , pi3k/akt/mtor pathway , signal transduction , cell culture , microbiology and biotechnology , immunology , genetics

PIK3R3 is a regulatory subunit of phosphatidylinositol 3-kinase (PI3K) which plays an essential role in the metastasis of several types of cancer. However, whether PIK3R3 can promote the metastasis of pancreatic cancer (PC) is still unclear. In this study, we characterized the role of PIK3R3 in metastasis of PC and underlying potential mechanisms.

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