Sumoylation Negatively Regulates CSR1-Dependent Prostate Cancer Cell Death | Zendy

Huarong Luo | Zendy; Ying Liu | Zendy; Xiaodong Wan | Zendy; Junliang Li | Zendy; Min Wu | Zendy; Qimin Zhang | Zendy; Denglong Wu | Zendy; Xin Zhao | Zendy; Tian-Ru Wang | Zendy

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Sumoylation Negatively Regulates CSR1-Dependent Prostate Cancer Cell Death

Author(s) -

Huarong Luo,

Ying Liu,

Xiaodong Wan,

Junliang Li,

Min Wu,

Qimin Zhang,

Denglong Wu,

Xin Zhao,

Tian-Ru Wang

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000489370

Subject(s) - sumo protein , prostate cancer , cancer research , biology , programmed cell death , cancer cell , transfection , cancer , apoptosis , cell growth , microbiology and biotechnology , cell culture , ubiquitin , gene , genetics

SUMOylation is a dynamic process and reversed by the activity of SUMO-specific proteases (SENPs) family. SENP1, a member of this family, is highly expressed and plays oncogenic roles in diverse cancers including prostate cancer. However, the SENP1-transgenic mice exhibit aberrant transformation of the mouse prostate gland but do not develop cancer. Cellular Stress Response 1 (CSR1) is a tumor suppressor gene and frequently deleted in prostate cancers. Overexpression of CSR1 in prostate cancer cells inhibits colony formation, anchorage-independent growth and induces cell death.

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