Icariin Restores Bone Structure and Strength in a Rat Model of Chronic High-Dose Alcohol-Induced Osteopenia
Author(s) -
Jiezhou Wu,
Pengcheng Liu,
Liu R,
Ming Cai
Publication year - 2018
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000489248
Subject(s) - osteopenia , icariin , osteoprotegerin , endocrinology , medicine , runx2 , osteocalcin , bone remodeling , bone mineral , bone resorption , chemistry , osteoporosis , alkaline phosphatase , activator (genetics) , receptor , pathology , biochemistry , alternative medicine , enzyme
Chronic alcohol abuse is an important risk factor for osteopenia. However, few studies have focused on the efficacy and mechanism of action of icariin on alcohol-induced osteopenia. The aim of this study was to investigate the efficacy and underlying mechanism of action of icariin in the treatment of chronic high-dose alcohol-induced osteopenia in a rat model.
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