MicroRNA-125b Affects Vascular Smooth Muscle Cell Function by Targeting Serum Response Factor | Zendy

Zhibo Chen | Zendy; Mian Wang | Zendy; Kai Huang | Zendy; Qiong He | Zendy; Honghao Li | Zendy; Guangqi Chang | Zendy

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MicroRNA-125b Affects Vascular Smooth Muscle Cell Function by Targeting Serum Response Factor

Author(s) -

Zhibo Chen,

Mian Wang,

Kai Huang,

Qiong He,

Honghao Li,

Guangqi Chang

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000489203

Subject(s) - neointima , vascular smooth muscle , microrna , flow cytometry , real time polymerase chain reaction , serum response factor , cell growth , microbiology and biotechnology , biology , chemistry , gene expression , medicine , endocrinology , restenosis , biochemistry , genetics , smooth muscle , gene , stent

Increasing evidence links microRNAs to the pathogenesis of peripheral vascular disease. We recently found microRNA-125b (miR-125b) to be one of the most significantly down‑regulated microRNAs in human arteries with arteriosclerosis obliterans (ASO) of the lower extremities. However, its function in the process of ASO remains unclear. This study aimed to investigate the expression, regulatory mechanisms, and functions of miR-125b in the process of ASO.

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