Major Differences in Hypoxia Tolerance and P38 Regulation Among Different Renal Cells | Zendy

Qianqian Shi | Zendy; Jian Shi | Zendy; Fengbao Luo | Zendy; Guanglai Song | Zendy; Xiaozhou He | Zendy; Ying Xia | Zendy

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Major Differences in Hypoxia Tolerance and P38 Regulation Among Different Renal Cells

Author(s) -

Qianqian Shi,

Jian Shi,

Fengbao Luo,

Guanglai Song,

Xiaozhou He,

Ying Xia

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000489188

Subject(s) - hypoxia (environmental) , p38 mitogen activated protein kinases , kinase , microbiology and biotechnology , kidney , mapk/erk pathway , biology , blot , chemistry , medicine , endocrinology , biochemistry , organic chemistry , oxygen , gene

Mitogen-activated protein kinases (MAPKs) are involved in the cellular response to hypoxia and their dysregulation may contribute to the progression and pathology of diverse human renal diseases. Recent studies suggest that the regulation of MAPK responses to hypoxic stress may be different in different cells, even within the same organ. However, it is unclear if MAPKs are differentially regulated in different renal cells in hypoxia. This work was carried out to clarify this fundamental issue.

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