MicroRNA-374 Exerts Protective Effects by Inhibiting SP1 Through Activating the PI3K/Akt Pathway in Rat Models of Myocardial Ischemia-Reperfusion After Sevoflurane Preconditioning | Zendy

Zhang Shu-bo | Zendy; Tiejun Liu | Zendy; Guo-Hua Pu | Zendy; Bao-Yong Li | Zendy; Xiaozeng Gao | Zendy; Xiaoliang Han | Zendy

Open Access

MicroRNA-374 Exerts Protective Effects by Inhibiting SP1 Through Activating the PI3K/Akt Pathway in Rat Models of Myocardial Ischemia-Reperfusion After Sevoflurane Preconditioning

Author(s) -

Zhang Shu-bo,

Tiejun Liu,

Guo-Hua Pu,

Bao-Yong Li,

Xiaozeng Gao,

Xiaoliang Han

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000489186

Subject(s) - protein kinase b , pi3k/akt/mtor pathway , tunel assay , downregulation and upregulation , apoptosis , sevoflurane , gsk3b , medicine , chemistry , pharmacology , biochemistry , gene

Ischemic heart disease is a leading cause of death in cardiovascular diseases, and microRNAs (miRs) have been reported to be potential therapeutic targets in heart disease. Herein, this study aims to investigate the effects of microRNA (miR)-374 on myocardial ischemia-reperfusion (I/R) injury in rat models pretreated with sevoflurane by targeting SP1 through the PI3K/Akt pathway.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research