AMPK Contributes to Cardioprotective Effects of Pterostilbene Against Myocardial Ischemia- Reperfusion Injury in Diabetic Rats by Suppressing Cardiac Oxidative Stress and Apoptosis | Zendy

Ramoji Kosuru | Zendy; Yin Cai | Zendy; Vidya Kandula | Zendy; Dan Yan | Zendy; Chunyan Wang | Zendy; Hong Zheng | Zendy; Yalan Li | Zendy; Michael G. Irwin | Zendy; Sanjay Singh | Zendy; Zhengyuan Xia | Zendy

Open Access

AMPK Contributes to Cardioprotective Effects of Pterostilbene Against Myocardial Ischemia- Reperfusion Injury in Diabetic Rats by Suppressing Cardiac Oxidative Stress and Apoptosis

Author(s) -

Ramoji Kosuru,

Yin Cai,

Vidya Kandula,

Dan Yan,

Chunyan Wang,

Hong Zheng,

Yalan Li,

Michael G. Irwin,

Sanjay Singh,

Zhengyuan Xia

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000489154

Subject(s) - pterostilbene , cardioprotection , ampk , medicine , oxidative stress , diabetes mellitus , streptozotocin , reperfusion injury , diabetic cardiomyopathy , endocrinology , lactate dehydrogenase , ischemia , pharmacology , protein kinase a , chemistry , kinase , resveratrol , heart failure , cardiomyopathy , biochemistry , enzyme

Pterostilbene (PT) exerts antidiabetic effects by decreasing blood glucose and modulating lipid metabolism and has been shown to attenuate myocardial ischemia-reperfusion (IR) injury in non-diabetic subjects. However, whether PT can protect against myocardial IR injury in diabetes is unknown. AMPK stimulation is indispensable in offering cardioprotection against myocardial IR injury in diabetes by limiting cardiac apoptosis. Thus, we hypothesized that PT may confer protection against myocardial IR injury in diabetes via AMPK activation.

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