Inhibition of LncRNA-HRIM Increases Cell Viability by Regulating Autophagy Levels During Hypoxia/Reoxygenation in Myocytes | Zendy

Zhouqing Huang | Zendy; Bozhi Ye | Zendy; Zhengxian Wang | Zendy; Jibo Han | Zendy; Lu Ning Lin | Zendy; Peiren Shan | Zendy; Xueli Cai | Zendy; Weijian Huang | Zendy

Open Access

Inhibition of LncRNA-HRIM Increases Cell Viability by Regulating Autophagy Levels During Hypoxia/Reoxygenation in Myocytes

Author(s) -

Zhouqing Huang,

Bozhi Ye,

Zhengxian Wang,

Jibo Han,

Lu Ning Lin,

Peiren Shan,

Xueli Cai,

Weijian Huang

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000489149

Subject(s) - myocyte , autophagy , ex vivo , viability assay , microbiology and biotechnology , biology , downregulation and upregulation , in vivo , cell , programmed cell death , hypoxia (environmental) , blot , small interfering rna , transfection , cell culture , chemistry , apoptosis , gene , oxygen , biochemistry , genetics , organic chemistry

Backgrund/Aims: Ischemia reperfusion (I/R) promotes the severity of cardiomyocyte injury. Long noncoding RNAs (LncRNAs) are key regulators in cardiovascular diseases. However, the association between LncRNAs and myocardial I/R injury has not been thoroughly characterized to date. We attempted to clarify the potential biological role of a LncRNA (E230034O05Rik), which we named hypoxia/reoxygenation (H/R) injury-related factor in myocytes (HRIM), by investigating the differential expression of LncRNAs between groups of myocytes exposed to either a normal level of oxygen or to H/R.

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