Intermittent Hypoxia Inhibits Na+-H+ Exchange-Mediated Acid Extrusion Via Intracellular Na+ Accumulation in Cardiomyocytes | Zendy

Huai-Ren Chang | Zendy; ChihFeng Lien | Zendy; JingRen Jeng | Zendy; JenChe Hsieh | Zendy; Chen-Wei Chang | Zendy; Jianhong Lin | Zendy; KunTa Yang | Zendy

Open Access

Intermittent Hypoxia Inhibits Na+-H+ Exchange-Mediated Acid Extrusion Via Intracellular Na+ Accumulation in Cardiomyocytes

Author(s) -

Huai-Ren Chang,

ChihFeng Lien,

JingRen Jeng,

JenChe Hsieh,

Chen-Wei Chang,

Jianhong Lin,

KunTa Yang

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000489076

Subject(s) - intracellular ph , acidosis , intracellular , amiloride , chemistry , hypoxia (environmental) , sodium–hydrogen antiporter , calcium in biology , medicine , endocrinology , pharmacology , biochemistry , sodium , oxygen , organic chemistry

Intermittent hypoxia (IH) has been shown to exert preconditioning-like cardioprotective effects. It also has been reported that IH preserves intracellular pH (pHi) during ischemia and protects cardiomyocytes against ischemic reperfusion injury. However, the exact mechanism is still unclear.

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