Induction of Pluripotent Stem Cell-Derived Cardiomyocyte Toxicity by Supernatant of Long Term-Stored Red Blood Cells in Vitro | Zendy

Fengyan Fan | Zendy; Yang Yu | Zendy; Liping Sun | Zendy; Shufang Wang | Zendy; Rui Wang | Zendy; Leiying Zhang | Zendy; Cuiying Li | Zendy; Deqing Wang | Zendy

Open Access

Induction of Pluripotent Stem Cell-Derived Cardiomyocyte Toxicity by Supernatant of Long Term-Stored Red Blood Cells in Vitro

Author(s) -

Fengyan Fan,

Yang Yu,

Liping Sun,

Shufang Wang,

Rui Wang,

Leiying Zhang,

Cuiying Li,

Deqing Wang

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000489073

Subject(s) - cardiotoxicity , induced pluripotent stem cell , toxicity , in vitro , immunofluorescence , stem cell , microbiology and biotechnology , pharmacology , chemistry , biology , gene , biochemistry , medicine , embryonic stem cell , immunology , antibody

Preserved red blood cells (RBCs) in vitro undergo a series of morphological, functional and metabolic changes during storage. RBC metabolites accumulate over time during storage, the toxicity of the supernatants of RBCs (SSRBCs) on tissue cells is largely unknown. Here, we aimed to study cardiomyocyte toxicity by supernatant of long term-stored RBCs in vitro and to discover elements involved in the mechanism.

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