Open AccessCRISPR-Cas9-Mediated Silencing of CD44 in Human Highly Metastatic Osteosarcoma Cells
Author(s) -
Liu Tang,
Zuyun Yan,
Yong Liu,
Edwin Choy,
Francis J. Hornicek,
Henry J. Mankin,
Zhenfeng Duan
Publication year - 2018
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000489072
Subject(s) - osteosarcoma , cd44 , metastasis , cancer research , gene silencing , medicine , biology , cell , cancer , gene , genetics
Metastasis is the major cause of death in patients with osteosarcoma. There is an urgent need to identify molecular markers that promote metastasis. Cluster of differentiation 44 is a receptor for hyaluronic acid (HA) and HA-binding has been proven to participate in various biological tumor activities, including tumor progression and metastasis.
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