Activated Α7nachr Improves Postoperative Cognitive Dysfunction and Intestinal Injury Induced by Cardiopulmonary Bypass in Rats: Inhibition of the Proinflammatory Response Through the Th17 Immune Response | Zendy

Keyan Chen | Zendy; Yingjie Sun | Zendy; Wanwei Dong | Zendy; Tiezheng Zhang | Zendy; Nan Zhou | Zendy; Weiwei Yu | Zendy; Yugang Diao | Zendy; Shanbin Guo | Zendy; Yue Tian | Zendy

Open Access

Activated Α7nachr Improves Postoperative Cognitive Dysfunction and Intestinal Injury Induced by Cardiopulmonary Bypass in Rats: Inhibition of the Proinflammatory Response Through the Th17 Immune Response

Author(s) -

Keyan Chen,

Yingjie Sun,

Wanwei Dong,

Tiezheng Zhang,

Nan Zhou,

Weiwei Yu,

Yugang Diao,

Shanbin Guo,

Yue Tian

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000489068

Subject(s) - proinflammatory cytokine , medicine , pharmacology , apoptosis , tunel assay , tumor necrosis factor alpha , immune system , neuroprotection , inflammation , immunology , endocrinology , chemistry , immunohistochemistry , biochemistry

Backgrund/Aims: To investigate the effects of activated α7 nicotinic acetylcholine receptor (α7nAChR) on postoperative cognitive dysfunction (POCD) and intestinal injury induced by cardiopulmonary bypass (CPB) and its relationship with the Th17 response in order to provide a theoretical basis for organ protection and targeted drug therapy during the perioperative period.

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